A painting hangs in the Metropolitan Museum of Art, New York called The Adoration of the Christ Child. Created in the 16th century by a Flemish artist, what stands out in this sublime presentation of the Nativity is the detail of the characters standing around the crib. Two of them, an angel and a shepherd, appear to have Down’s Syndrome.
This suggests that the condition has been around for a very long time, and it helps illuminate the early modern approach to disability. Religious art normally conformed to classical standards of beauty. By implication, the artist regarded people with Down’s as angelic. As, indeed, they are.